Upregulation of Neutrophil Surface Adhesion Molecules in Infants of Pre-eclamptic Women
| Autor: | Michael Costello, Denise B. Angst, Hemant Saini, Alice Gilman-Sachs, Bhagya L. Puppala |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Integrins Neutrophils CD11c CD18 CD11a Neutrophil Activation Flow cytometry Andrology Pre-Eclampsia Downregulation and upregulation Pregnancy medicine Humans Placental Circulation medicine.diagnostic_test biology Cell adhesion molecule business.industry Infant Newborn Obstetrics and Gynecology Fetal Blood Flow Cytometry Up-Regulation Integrin alpha M Case-Control Studies Cord blood Pediatrics Perinatology and Child Health Immunology biology.protein Female business Cell Adhesion Molecules |
| Zdroj: | Journal of Perinatology. 24:208-212 |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | OBJECTIVE: To evaluate evidence of neutrophil activation in infants born to pre-eclamptic women and examine any association between degree of neutrophil activation and severity of pre-eclampsia. DESIGN: This study utilized quantitative flow cytometry to determine whether the expression of surface adhesion molecules: CD18, CD11a, CD11b, and CD11c on cord blood neutrophils using mean channel fluorescence values (MCF). A total of 20 infants of pre-eclamptic women were compared with a control group of 19 infants of normotensive women. RESULTS: MCF values were significantly higher in infants born to pre-eclamptic women vs controls: CD18 (432.0±236.3 vs 230.5±97.9; p=0.002), CD11a (552.9±272.4 vs 326.9±268.6; p=0.003), CD11b (937.2±521.9 vs 576.6±352.9; p=0.025), and CD11c (228.5±130.3 vs 133.0±77.1; p=0.006), respectively. The mean MCF values appeared higher in severe vs mild pre-eclampsia. CONCLUSIONS: This study revealed neutrophil activation in infants born to pre-eclamptic women. The relationship between neutrophil activation and severity of pre-eclampsia warrants further study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|