Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state
| Autor: | Dybesh Regmi, Romona D. Govender, Juma Al Kaabi, Saif Al-Shamsi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Population diabetes & endocrinology United Arab Emirates lcsh:Medicine Overweight Cohort Studies Prediabetic State Risk Factors medicine Humans Outpatient clinic Obesity education Proportional Hazards Models Retrospective Studies education.field_of_study business.industry Incidence Incidence (epidemiology) lcsh:R Type 2 Diabetes Mellitus Retrospective cohort study General Medicine Middle Aged medicine.disease Diabetes and Endocrinology internal medicine Diabetes Mellitus Type 2 epidemiology Female medicine.symptom business Body mass index |
| Zdroj: | BMJ Open, Vol 10, Iss 7 (2020) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesA high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity. Nonetheless, no data are available regarding the incidence of type 2 DM in the high-risk adult UAE population. Therefore, this study aimed to evaluate the incidence rate and risk of developing type 2 DM among individuals with above-normal BMI in the UAE.DesignA retrospective cohort study.SettingOutpatient clinics at a tertiary care centre in Al Ain, UAE.ParticipantsThree hundred and sixty-two overweight or obese adult UAE nationals who visited outpatient clinics between April 2008 and December 2008.Primary outcome measurePatients with type 2 DM were identified based on diagnosis established by a physician or through glycated haemoglobin (HbA1c) levels ≥6.5% during the follow-up period (until April 2018).ResultsThe overall incidence rate of type 2 DM during the median follow-up time of 8.7 years was 16.3 (95% CI 12.1 to 21.4) cases per 1000 person-years. Incidence rates in men and women were 17.7 (95% CI 11.6 to 25.9) and 15.0 (95% CI 9.8 to 22.2) cases per 1000 person-years, respectively. Multivariable Cox proportional hazard analysis determined older age and obesity in women and pre-diabetes in men to be independent risk factors for developing type 2 DM.ConclusionsThe incidence rate of type 2 DM in overweight and obese UAE nationals is high. In addition to screening, current strategies should strongly emphasise lifestyle modifications to decrease HbA1c and BMI levels in this high-risk population. |
| Databáze: | OpenAIRE |
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