Effects of duodenal seal oil administration in patients with inflammatory bowel disease
| Autor: | Linn Anne Brunborg, Merete Valen, Livar Frøyland, Gülen Arslan, Johan G. Brun, Arnold Berstad |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Duodenum Seals Earless Administration Oral Biochemistry Inflammatory bowel disease Gastroenterology Crohn Disease Internal medicine medicine Animals Humans Longitudinal Studies Intestinal permeability business.industry Organic Chemistry Cell Biology Colitis Inflammatory Bowel Diseases Fish oil medicine.disease Arthralgia Ulcerative colitis medicine.anatomical_structure Joint pain Chronic Disease Fatty Acids Unsaturated Female Calprotectin medicine.symptom business Oils Lipidology |
| Zdroj: | Lipids. 37:935-940 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-006-0983-2 |
| Popis: | Long-chain n-3 PUFA in fish oil have modulating effects on inflammatory responses. The aim of this open pilot study was to investigate whether duodenal seal oil administration would benefit patients with inflammatory bowel disease (IBD). Seal oil (10 mL) was administered three times a day directly into the distal part of the duodenum via a nasoduodenal feeding tube for 10 d in 10 patients, 5 of whom had Crohn's disease and 5 ulcerative colitis. Nine of the 10 patients suffered from IBD-associated joint pain. Various parameters of disease activity and FA incorporation in tissues were analyzed before and after treatment. Following seal oil therapy, joint pain index, disease activity, and serum cholesterol level were significantly decreased, whereas the n-3 to n-6 ratio both in intestinal biopsies and blood was significantly increased. Measures of calprotectin concentration in gut lavage fluid, intestinal permeability, and lipid peroxidation were not significantly changed. The results suggest positive effects of seal oil in patients with IBD, especially on IBD-associated joint pain. Further controlled studies are warranted. |
| Databáze: | OpenAIRE |
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