| Autor: |
Christie K. Campla, Ulisse Bocchero, Ryan Strickland, Jacob Nellissery, Jayshree Advani, Irina Ignatova, Dhiraj Srivastava, Angel M. Aponte, Yuchen Wang, Jessica Gumerson, Kirill Martemyanov, Nikolai O. Artemyev, Johan Pahlberg, Anand Swaroop |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
eNeuro. 9(5) |
| ISSN: |
2373-2822 |
| Popis: |
Trafficking of transducin (Gαt) in rod photoreceptors is critical for adaptive and modulatory responses of the retina to varying light intensities. In addition to fine-tuning phototransduction gain in rod outer segments (OSs), light-induced translocation of Gαtto the rod synapse enhances rod to rod bipolar synaptic transmission. Here, we show that the rod-specific loss of Frmpd1 (FERM and PDZ domain containing 1), in the retina of both female and male mice, results in delayed return of Gαtfrom the synapse back to outer segments in the dark, compromising the capacity of rods to recover from light adaptation. Frmpd1 directly interacts with Gpsm2 (G-protein signaling modulator 2), and the two proteins are required for appropriate sensitization of rod-rod bipolar signaling under saturating light conditions. These studies provide insight into how the trafficking and function of Gαtis modulated to optimize the photoresponse and synaptic transmission of rod photoreceptors in a light-dependent manner. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
