The survival of rat cerebral cortical neurons in the presence of trophic APP peptides
| Autor: | Kazuaki Kawashima, Jean-Marc Roch, Toshio Miyoshi, Hiroaki Araki, Tsunao Saitoh, Tetsuji Yae, Kyoko Yamamoto, Deborah A. C. Otero, Kazunori Hanada |
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| Rok vydání: | 1994 |
| Předmět: |
Amyloid
Cell Survival Molecular Sequence Data Mutant Peptide Biology medicine.disease_cause Amyloid beta-Protein Precursor Cellular and Molecular Neuroscience Alzheimer Disease mental disorders Neurites medicine Animals Amino Acid Sequence Nerve Growth Factors Rats Wistar Escherichia coli Peptide sequence Cells Cultured Cerebral Cortex Neurons chemistry.chemical_classification General Neuroscience Cell Differentiation Cortical neurons Fibroblasts Peptide Fragments Rats Amino acid Cell biology chemistry Neuroscience Cell Division Function (biology) |
| Zdroj: | Journal of Neurobiology. 25:585-594 |
| ISSN: | 1097-4695 0022-3034 |
| Popis: | One function of Alzheimer amyloid protein precursor (APP) is the regulation of growth and differentiation in several types of cells, including fibroblasts, PC12 cells, and neurons. This activity is represented by a small stretch of amino acids in the center of the molecule around RERMS. The APP 17-mer peptide containing the RERMS domain supported survival and neurite extension of rat cortical neurons in a dose-dependent and sequence-specific manner. The APP fragment synthesized in Escherichia coli supported the survival and neurite extension of rat cortical neurons, whereas the mutant APP fragment lacking the 30 amino acids around the RERMS domain had drastically reduced activity to support the survival and neurite extension. The current study established APP as a neuron survival factor and determined that the sequence around RERMS is important for this function. |
| Databáze: | OpenAIRE |
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