Potential association of DRD2 and DAT1 genetic variation with heroin dependence
| Autor: | Shengbin Li, Qiao-Fang Hou |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male China TaqI Biology Polymorphism Single Nucleotide Risk Assessment chemistry.chemical_compound Gene interaction Risk Factors mental disorders Genotype Genetic variation Prevalence Humans Genetic Predisposition to Disease Allele Genotyping Dominance (genetics) Genetics Dopamine Plasma Membrane Transport Proteins Heroin Dependence Receptors Dopamine D2 General Neuroscience Genetic Variation chemistry Female Restriction fragment length polymorphism |
| Zdroj: | Neuroscience Letters. 464:127-130 |
| ISSN: | 0304-3940 |
| Popis: | The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3′untranslated region VNTR genetic variations with heroin addiction. Genotyping was performed using PCR-based techniques in 530 heroin abusers and 500 controls. Our results showed that DRD2 TaqI A1 allele carriers (genotypes A1A1 and A1A2) were prone to heroin abuse in models of dominance or co-dominance. We detected a 12 repeat allele and 6/6, 7/9, 9/11, 10/12 genotype in a Chinese/eastern Asian population for the first time. However, no significant differences in the DAT1 VNTR were found between the two groups in either genotypic or allelic distributions and there was no gene interaction between the two genetic loci. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect