Renal insufficiency associated with intramuscular administration of ketorolac tromethamine
| Autor: | Robin L. Corelli, Kristin R Gericke |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Renal function 030226 pharmacology & pharmacy Ketorolac Tromethamine Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Renal Insufficiency Tolmetin Tromethamine Aged Aged 80 and over Creatinine business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged medicine.disease Discontinuation body regions Ketorolac Drug Combinations chemistry Anesthesia Toxicity Female business Adverse drug reaction medicine.drug |
| Zdroj: | The Annals of pharmacotherapy. 27(9) |
| ISSN: | 1060-0280 |
| Popis: | OBJECTIVE: To evaluate reports of renal toxicity associated with intramuscular ketorolac tromethamine. Medical charts were reviewed for all cases of renal toxicity associated with ketorolac therapy. METHODS: Patients with possible ketorolac-associated nephrotoxicity were identified through our institution's adverse drug reaction reporting program. Patients were included in this report if: (1) renal insufficiency was temporally related to ketorolac administration; (2) resolution of renal insufficiency occurred after discontinuation of ketorolac; and (3) no other causes of renal insufficiency, including other medications, could be identified. RESULTS: Six patients had renal insufficiency secondary to ketorolac administration. The mean age of the patients was 58 years and cardiovascular disease was present in five. Serum creatinine values increased from a mean of 106 ± 26 μmol/L (1.2 ± 0.3 mg/dL) to a mean peak value of 256 ± 195 μmol/L (2.9 ± 2.2 mg/dL). Recovery of renal function was observed after a mean of 2.3 ± 0.5 days. CONCLUSIONS: Short-term administration of ketorolac can be associated with reversible oliguric renal insufficiency. Indiscriminate use of ketorolac for pain management in place of narcotic analgesics should be avoided, especially in patients at high risk for toxicity induced by nonsteroidal antiinflammatory drugs. |
| Databáze: | OpenAIRE |
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