A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line
| Autor: | Fabrizio Romano, Giacomo Cuttone, Ivan Petrović, A. Varisano, F. Di Rosa, S. E. Mazzaglia, A. Ristic Fira, G.A.P. Cirrone |
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| Rok vydání: | 2014 |
| Předmět: |
Proton
Bragg peak Physics::Medical Physics Hadron Monte Carlo method Linear energy transfer Heavy Ion Radiotherapy Tracking (particle physics) 030218 nuclear medicine & medical imaging Ion 03 medical and health sciences 0302 clinical medicine hadrontherapy Proton Therapy Linear Energy Transfer Radiology Nuclear Medicine and imaging Monte Carlo simulation Physics linear energy transfer Radiological and Ultrasound Technology Radiobiology Radiotherapy Dosage biological effect 030220 oncology & carcinogenesis Absorbed dose Atomic physics Monte Carlo Method Beam (structure) |
| Zdroj: | Physics in Medicine and Biology |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/59/12/2863 |
| Popis: | Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures. |
| Databáze: | OpenAIRE |
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