Neutrophil-to-lymphocyte ratio decreases in obstructive sleep apnea treated with mandibular advancement devices
| Autor: | Moh’d Al-Halawani, Sreelatha Naik, Meir H. Kryger, Michael Chan, Jonathan Meiers, Iouri Kreinin |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Neutrophils Subgroup analysis Inflammation 030204 cardiovascular system & hematology Systemic inflammation Gastroenterology Hypoxemia 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Lymphocytes Neutrophil to lymphocyte ratio Subclinical infection Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry fungi Middle Aged medicine.disease Obstructive sleep apnea Otorhinolaryngology Female Neurology (clinical) medicine.symptom Inflammation Mediators business Mandibular Advancement 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Sleepbreathing = SchlafAtmung. 22(4) |
| ISSN: | 1522-1709 |
| Popis: | Obstructive sleep apnea has been associated with chronic inflammation triggered by nocturnal hypoxemia. The neutrophil-to-lymphocyte ratio (NLR) is a measure of subclinical systemic inflammation. We hypothesize that NLR levels would improve as chronic inflammation diminishes in obstructive sleep apnea (OSA) patients treated with mandibular advancement devices (MADs). We studied patients with OSA who were treated with MAD as a first-line treatment or because they could not tolerate CPAP. We obtained pre-treatment and post-treatment complete blood counts. NLR was calculated by dividing the number of neutrophils by the number of lymphocytes obtained from the CBCs. Patients with other conditions known to affect NLR were excluded from the study. We compared the values of NLR and oxygen desaturation index (ODI) before and after treatment with MAD in 22 patients who met inclusion criteria and completed the study protocol. There was a significant difference in NLR before and after treatment (p = 0.01). There was also a significant difference in the 3% ODI and 4% ODI before and after treatment with MAD (p = 0.014, 0.007), respectively. A subgroup analysis compared NLR in two groups of patients, the optimally treated and suboptimally treated. There was a significant decrease in the NLR in the optimally treated group (n = 10) (p |
| Databáze: | OpenAIRE |
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