Association between influenza vaccination and reduced risks of major adverse cardiovascular events in elderly patients
| Autor: | Hau-Hsin Wu, Chia-Jen Shih, Yung Tai Chen, Ming-Hsien Chiang, Te-Li Chen, Shu-Chen Kuo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Influenza vaccine Population Taiwan 03 medical and health sciences 0302 clinical medicine Internal medicine Influenza Human Odds Ratio medicine Humans cardiovascular diseases 030212 general & internal medicine education Aged Retrospective Studies education.field_of_study business.industry Incidence Incidence (epidemiology) Vaccination Age Factors Case-control study Retrospective cohort study Odds ratio Surgery Cardiovascular Diseases Influenza Vaccines Case-Control Studies Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Mace Follow-Up Studies |
| Zdroj: | American Heart Journal. 193:1-7 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/j.ahj.2017.07.020 |
| Popis: | This study was conducted to determine the protective effect of influenza vaccine against primary major adverse cardiovascular events (MACEs) in elderly patients, especially those with influenza-like illness (ILI).This retrospective, population-based case-control study of an elderly population (age≥65 years) was conducted using Taiwan's National Health Insurance Research Database (2000-2013). One control was selected for each MACE case (n=80,363 each), matched according to age, year of study entry, and predisposing factors for MACEs. ILI and MACEs (myocardial infarction [MI] and ischemic stroke) were defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification. Odds ratios (ORs) were calculated for the association between MACEs and vaccination.Influenza vaccination received in the previous year was associated with reduced risks of primary MACEs overall (adjusted OR [aOR] 0.80, 95% CI 0.78-0.82, P.001), MI (aOR 0.80, 95% CI 0.76-0.84, P.001), and ischemic stroke (aOR 0.80, 95% CI 0.77-0.82, P.001). ILI diagnosed in the previous year was associated with increased risks of MACEs (aOR 1.24, 95% CI 1.18-1.29, P.001), MI (aOR 1.46, 95% CI 1.34-1.59, P.001), and ischemic stroke (aOR 1.16, 95% CI 1.10-1.22, P.001). Vaccination attenuated the heightened risks associated with ILI (MACEs: aOR 0.99, 95% CI 0.92-1.07, P=.834; MI: aOR 1.05, 95% CI 0.92-1.21, P=.440; ischemic stroke: aOR 0.96, 95% CI 0.89-1.05, P=.398).Results of this study suggest that influenza vaccination is associated with reduced primary MACE risks in the elderly population, including those with ILI. |
| Databáze: | OpenAIRE |
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