Epigenetic silencing of a multifunctional plant stress regulator
| Autor: | Robert J. Schmitz, Mark Zander, Anna Bartlett, Ramlah Nehring, Huaming Chen, Elizabeth Howell, Mathew G. Lewsey, Joanne Chory, Robert B. McGrath, Florian Jupe, Björn C. Willige, Joseph R. Ecker, Yupeng He, Rosa Castanon, Joseph R. Nery, Thu A Nguyen, Zhuzhu Zhang, Amber E. Langford, Anna Stepanova |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine QH301-705.5 Science plant epigenomics Arabidopsis Regulator Plant Biology Receptors Cell Surface 01 natural sciences General Biochemistry Genetics and Molecular Biology Chromatin remodeling chromatin remodeling Epigenesis Genetic 03 medical and health sciences Histone demethylation Gene Expression Regulation Plant ethylene Ino80 complex Biology (General) Enhancer histone demethylation General Immunology and Microbiology biology Arabidopsis Proteins General Neuroscience Nuclear Proteins Genetics and Genomics General Medicine Ethylenes Chromatin Cell biology 030104 developmental biology Histone A. thaliana biology.protein Medicine Demethylase Research Article Signal Transduction Transcription Factors 010606 plant biology & botany |
| Zdroj: | eLife eLife, Vol 8 (2019) |
| ISSN: | 2050-084X |
| Popis: | The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A.Z at the 5’ untranslated region (5’UTR) intron of EIN2. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at EIN2 to a repressive state causing a dramatic reduction of EIN2 expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator. |
| Databáze: | OpenAIRE |
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