Coenzyme Q10 effect on cisplatin-induced oxidative retinal injury in rats
| Autor: | Nezahat Kurt, Renad Mammadov, Mukadder Sunar, Halis Suleyman, Gulce Naz Yazici, Yusuf Kemal Arslan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Coenzyme Q10
Cisplatin Male Retinal damage Ubiquinone Administration Oral General Medicine Retinal injury Oxidative phosphorylation Pharmacology Toxicology Antioxidants Retina Rats Oxidative damage chemistry.chemical_compound Disease Models Animal Oxidative Stress chemistry Retinal Diseases medicine Animals Humans medicine.drug |
| Zdroj: | Cutaneous and ocular toxicology. 40(4) |
| ISSN: | 1556-9535 |
| Popis: | In this study, it was aimed to investigate the effect of coenzyme Q10 (CoQ10) on cisplatin-induced oxidative retinal damage in rats biochemically and histopathologically.Thirty male Wistar albino rats were divided into 3 groups randomly: untreated control (C group), only 2.5 mg/kg cisplatin daily administrated group for 2 weeks (CP group), 2.5 mg/kg cisplatin + 20 mg/kg orally CoQ10 daily administrated group for 2 weeks (CoQC group). At the end of experimental period, blood samples obtained before sacrification for the biochemical examination of serum malondialdehyde (MDA), total glutathione (tGSH), total oxidant system (TOS), total antioxidant systemic (TAS) levels and after eyes were removed for examined histopathology.As a result of our study, severe histopathological damage was detected in the retinal tissue of the cisplatin group with serum malondialdehyde (MDA) and total oxidant system (TOS) levels were high and total glutathione (tGSH) and total antioxidant systemic (TAS) levels were low. However, it was observed that the histopathological damage associated with cisplatin was decreased in the retinal tissue of the CoQ10 group, which inhibited the increase in blood serum MDA/TOS levels and decrease in tGSH/TAS levels.The biochemical and histopathological results of our study were compatible with each other, so we concluded that the damage to the rat retinal tissue caused by cisplatin may be reversible with coenzyme. |
| Databáze: | OpenAIRE |
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