Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia

Autor:	Tran Tinh Hien, Pilaipan Puthavathana, Suhud Malik, Sherine Thomas, Diep N. Nguyen, Menno D. de Jong, Sinh Thi Tran, Khanh Huu Truong, Trung Vu Nguyen, Kulkanya Chokephaibulkit, Dung Viet Tien Vu, Tuan Manh Ha, Marcel Wolbers, Walter R. J. Taylor, Liem Thanh Nguyen, Uyen Hanh Nguyen, Heiman F. L. Wertheim, Kinh Van Nguyen, Agustiningsih, Jeremy Farrar, H. Rogier van Doorn, Thuy Bich Thi Phung, Behzad Nadjm, Chau Vinh Van Nguyen
Přispěvatelé:	Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Pulmonary and Respiratory Medicine Mycoplasma pneumoniae Oseltamivir Atypical bacteria Epidemiology viruses respiratory tract infections medicine.disease_cause Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Case fatality rate Hospitalisation Medicine 030212 general & internal medicine 0303 health sciences Respiratory tract infections 030306 microbiology business.industry Public Health Environmental and Occupational Health RSV virus diseases Original Articles Virology 3. Good health Infectious Diseases rhinovirus chemistry Etiology Rhinovirus business influenza
Zdroj:	Influenza and Other Respiratory Viruses Influenza and other respiratory viruses, 9(6), 315-322. Wiley-Blackwell
ISSN:	1750-2659
DOI:	10.1111/irv.12326
Popis:	Background Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the aetiology of infection presenting clinically as influenza in hospitalised adults and children in South-East Asia. Such data are important for future management of respiratory infections. Objectives To describe the aetiology of infection presenting clinically as influenza in those hospitalised in South-East Asia. Methods Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction. Results A total of 1222 patients’ samples were tested. Of 1222, 776 patients (63·5%) were under the age of 5. Viruses detected included rhinoviruses in 229 of 1222 patients (18·7%), bocaviruses in 200 (16·4%), respiratory syncytial viruses in 144 (11·8%), parainfluenza viruses in 140 (11·5%; PIV1: 32; PIV2: 12; PIV3: 71; PIV4: 25), adenovirus in 102 (8·4%), influenza viruses in 93 (7·6%; influenza A: 77; influenza B: 16) and coronaviruses in 23 (1·8%; OC43: 14; E229: 9). Bacterial pathogens were Mycoplasma pneumoniae (n = 33, 2·7%), Chlamydophila psittaci (n = 2), C. pneumoniae (n = 1), Bordetella pertussis (n = 1) and Legionella pneumophila (n = 2). Overall, in-hospital case fatality rate was 29 of 1222 (2·4%). Conclusion Respiratory viruses were the most commonly detected pathogens in patients hospitalised with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae, the most common atypical bacterium. The low number of detected influenza viruses demonstrates a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak.
Databáze:	OpenAIRE
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