Trans-8, cis-10+ cis-9, trans-11-conjugated linoleic acid mixture alters body composition in Syrian golden hamsters fed a hypercholesterolaemic diet
| Autor: | Andrew P. Wakefield, Shama V. Joseph, P. Yvan Chouinard, Xiaoran Liu, Hélène Jacques, Peter B. Jones, Harold M. Aukema |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Conjugated linoleic acid Linoleic acid Hypercholesterolemia Medicine (miscellaneous) Blood sugar chemistry.chemical_compound Eating Feces Random Allocation Blood serum Internal medicine Cricetinae medicine Animals Linoleic Acids Conjugated Nutrition and Dietetics medicine.diagnostic_test biology Mesocricetus Cholesterol Body Weight Organ Size biology.organism_classification Animal Feed Dietary Fats Diet Endocrinology chemistry Liver Dietary Supplements Lean body mass Body Composition Lipid profile |
| Zdroj: | The British journal of nutrition. 104(10) |
| ISSN: | 1475-2662 |
| Popis: | The effectiveness of conjugated linoleic acid (CLA) as a weight-loss nutraceutical continues to be debatable, suggesting that there may be value in exploring the physiological effects of the lesser-known isomers. The effects of the minor isomer,trans-8,cis-10 (t8,c10)-CLA, in the form of an equimolar mixture with thecis-9,trans-11 (c9,t11) isomer, on body weight and body composition, circulating glucose and lipid concentrations, and liver weights were studied in sixty male Syrian golden hamsters. Animals were randomised to receive for 28 d a semi-purified, hypercholesterolaemic diet (5 % dietary fat and 0·25 % cholesterol) supplemented at the 2 % level with either thet8,c10+c9,t11-CLA mixture,c9,t11-CLA ortrans-10,cis-12 (t10,c12)-CLA replacing lard and safflower-seed oil (control). Results show that compared with control, thet8,c10+c9,t11-CLA mixture andt10,c12-CLA-fed animals had lower (P t10,c12-CLA also possessed higher lean mass compared with control andc9,t11-CLA groups (P P P t10,c12-CLA compared with thec9,t11 isomer. Overall, these results indicate that in male hamsters fed a hypercholesterolaemic diet, thet8,c10+c9,t11-CLA mixture does not have an impact on blood lipid profile, but is able to effectively reduce fat mass, without incurring an accompanying liver enlargement. |
| Databáze: | OpenAIRE |
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