Effects of Glucocorticoids on Apoptosis and Clearance of Apoptotic Cells

Autor: Sylwia Michlewska, Ian Dransfield, Adriano G. Rossi, Aisleen McColl
Rok vydání: 2007
Předmět:
Transcriptional Activation
Phagocytosis
Cell
Drug Resistance
lcsh:Medicine
Inflammation
Review Article
Biology
lcsh:Technology
Histone Deacetylases
Monocytes
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Receptors
Glucocorticoid
0302 clinical medicine
Glucocorticoid receptor
medicine
Animals
Humans
lcsh:Science
Receptor
Psychological repression
Histone Acetyltransferases
030304 developmental biology
General Environmental Science
0303 health sciences
glucocorticoids
lcsh:T
Macrophages
lcsh:R
apoptosis
Cell Differentiation
General Medicine
Chromatin Assembly and Disassembly
3. Good health
macrophage phagocytosis
medicine.anatomical_structure
Proto-Oncogene Proteins c-bcl-2
Apoptosis
Immunology
Cancer research
lcsh:Q
medicine.symptom
Glucocorticoid
030215 immunology
medicine.drug
Zdroj: McColl, A, Michlewska, S, Dransfield, I & Rossi, A G 2007, ' Effects of glucocorticoids on apoptosis and clearance of apoptotic cells ', Scientific World Journal, vol. 7, pp. 1165-81 . https://doi.org/10.1100/tsw.2007.224
The Scientific World Journal, Vol 7, Pp 1165-1181 (2007)
The Scientific World Journal
ISSN: 1537-744X
DOI: 10.1100/tsw.2007.224
Popis: The glucocorticoid (GC) drugs are one of the most commonly prescribed and effective anti-inflammatory agents used for the treatment of many inflammatory disorders through their ability to attenuate phlogistic responses. The glucocorticoid receptor (GCR) primarily mediates GC actions via activation or repression of gene expression. GCs directly induce the expression of proteins displaying anti-inflammatory activities. However, the likely predominant effect of GCs is the repression of multiple inflammatory genes that invariably are overexpressed during nonresolving chronic inflammation. Although most GC actions are mediated through regulation of transcription, rapid nongenomic actions have also been reported. In addition, GCs modulate inflammatory cell survival, inducing apoptosis in immature thymocytes and eosinophils, while delaying constitutive neutrophil apoptosis. Importantly, GCs promote noninflammatory phagocytosis of apoptotic cell targets, a process important for the successful resolution of inflammation. Here, the effects and mechanisms of action of GC on inflammatory cell apoptosis and phagocytosis will be discussed.
Databáze: OpenAIRE
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