Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy
| Autor: | Ana Paula Murray, María Julia Castro, María Belén Faraoni, Natalia Paola Alza, Valeria Cavallaro |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
plant extracts
Aché Disease Neurological disorder Bioinformatics Article chemistry.chemical_compound PLANT EXTRACTS medicine Pharmacology (medical) Alzheimer’s Disease Neurotransmitter Pharmacology chemistry.chemical_classification ACETYLCHOLINESTERASE INHIBITORS secondary metabolites business.industry Ciencias Químicas General Medicine medicine.disease Acetylcholinesterase language.human_language Psychiatry and Mental health Química Orgánica Enzyme ALZHEIMER'S DISEASE SECONDARY METABOLITES Neurology chemistry acetylcholinesterase inhibitors language Cholinergic Neurology (clinical) essential oils business CIENCIAS NATURALES Y EXACTAS Acetylcholine medicine.drug |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x11311040004 |
| Popis: | As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer's disease and alleviating the symptoms of this neurological disorder. This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition. Fil: Murray, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina Fil: Faraoni, María Belén. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina Fil: Castro, Maria Julia. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina Fil: Alza, Natalia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina Fil: Cavallaro, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina |
| Databáze: | OpenAIRE |
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