Hypersensitivity reactions to low molecular weight heparins: different patterns of cross-reactivity in 3 patients
| Autor: | Viktorija Erdeljić Turk, I. Cegec, Iveta Šimić, Danica Juričić Nahal, Ksenija Makar Ausperger, I. Kraljickovic |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Pharmacology Physiology Chemistry General Medicine Cross Reactions Heparin Low-Molecular-Weight medicine.disease_cause Cross-reactivity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Physiology (medical) Immunology Hypersensitivity medicine Humans Female Skin Tests |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 96:428-432 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2017-0246 |
| Popis: | Low molecular weight heparins (LMWHs) are used for a variety of indications. The most common type of hypersensitivity reactions to LMWHs are delayed-type hypersensitivity reactions (DHR). Immediate-type hypersensitivity reactions (IHR) occur only sporadically. Cross-reactivity of different LMWHs is a common and unpredictable problem. We present 2 cases of patients who developed DHR to nadroparin and enoxaparin, respectively. The third case presents a patient who developed IHR to nadroparin. Skin tests confirmed the hypersensitivity in all cases. In the cases of DHR, a skin test negative LMWH was identified and was tolerated in a challenge test. In the IHR case, cross-reactivity to all tested LMWHs was established. We hypothesize that the degree of cross-reactivity might depend on the type of hypersensitivity reaction with immediate reactions linked to more extensive cross-reactivity than delayed reactions. This is important to consider because, at least in some cases, a safe alternative LMWH can be identified. |
| Databáze: | OpenAIRE |
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