Influenza a H1N1 associated acute glomerulonephritis in an adolescent
| Autor: | Eleni Antonopoulou, Ioannis Drikos, Panagiotis Roungas, Dimitris Kyriazopoulos, Antigoni Pegkou, Eleni Papa, Garyfallia Syridou, Olga Savelieva, Artemis Vintila, Loukia Zografou |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Oseltamivir Acute glomerulonephritis 030106 microbiology Context (language use) Infectious and parasitic diseases RC109-216 Virus Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Influenza complications medicine 030212 general & internal medicine Hematuria business.industry virus diseases Glomerulonephritis medicine.disease Pharyngitis Influenza Infectious Diseases Otitis chemistry medicine.symptom Differential diagnosis Complication business |
| Zdroj: | IDCases, Vol 19, Iss, Pp-(2020) IDCases |
| ISSN: | 2214-2509 |
| Popis: | Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children. Acute glomerulonephritis as a complication of H1N1 influenza virus infection has been described only sporadically.Herein we present a case of acute glomerulonephritis in a previously healthy adolescent, in the context of infection with influenza A H1N1 virus.A 15-year old adolescent was admitted to our pediatric department due to fever, pharyngitis, cough, vomit, dizziness and fatigue. Based on his symptoms and the seasonal epidemiology, empiric treatment with oseltamivir was initiated while waiting for RT-PCR for influenza virus in pharyngeal swab, which was positive for A H1N1 influenza virus. In the first 24 h of admission, the patient presented macroscopic haematuria, which completely subsided in the following days, along with fever recession. The urine microscopic analysis showed findings compatible with acute glomerulonephritis. The patient remained normotasic while his biochemical profile including renal function, as well as further investigation of hematuria (immunoglobulins, C3, C4, ANA, anti-DNA, U/S) were all normal.ASTO levels, which were initially above normal (562 IU/ml), did not increase significantly in the following days, and given the fact that C3 levels were constantly within normal limits and pharyngeal culture was negative for pyogenic streptococcus, they were not considered sufficient for poststreptococcal glomerulonephritis diagnosis.Physicians should be suspicious and include influenza in the differential diagnosis when children present with uncommon symptoms such as hematuria along with even mild respiratory symptoms, during seasonal influenza period. Keywords: Influenza, Acute glomerulonephritis, Hematuria, Influenza complications |
| Databáze: | OpenAIRE |
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