Synthesis of Imidazopyridines and Purines as Potent Inhibitors of Leukotriene A4 Hydrolase

Autor:	Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro
Rok vydání:	2003
Předmět:	Imidazopyridine Pyridines Clinical Biochemistry Pharmaceutical Science Purine analogue In Vitro Techniques Biochemistry Chemical synthesis Leukotriene-A4 hydrolase Mice Structure-Activity Relationship Heterocyclic Compounds Drug Discovery Animals Humans Structure–activity relationship Enzyme Inhibitors Purine metabolism Molecular Biology Epoxide Hydrolases biology Chemistry Organic Chemistry Recombinant Proteins stomatognathic diseases Purines Enzyme inhibitor biology.protein Molecular Medicine Indicators and Reagents Ex vivo
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:1137-1139
ISSN:	0960-894X
Popis:	The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excellent potency in our in vitro assays, as well as good oral activity in a mouse ex vivo assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9 https://doi.org/10.1016/s0960-894x(03)00039-8 Zobrazit plný text záznamu Full Text from ScienceDirect