Cerebral cell renewal in adult mice controls the onset of obesity
| Autor: | Sylvian Bauer, Jean Gascuel, Emmanuelle Nédélec, Aleth Lemoine, Alice Krezymon, Alexandre Benani, Xavier Brenachot, Caroline Rigault, Luc Penicaud, Alexandra Gouazé, Camille Rauch |
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| Přispěvatelé: | BENANI, Alexandre, Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Fonds de recherche : Burgundy county : FABER-2009-9201-AAO036S00635, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Central Nervous System
Male Anatomy and Physiology Pro-Opiomelanocortin Mouse Cell lcsh:Medicine Weight Gain Neurological Signaling Mice 0302 clinical medicine Endocrinology Molecular Cell Biology lcsh:Science Neurons 0303 health sciences Multidisciplinary digestive oral and skin physiology Animal Models Signaling in Selected Disciplines medicine.anatomical_structure Hypothalamus Alimentation et Nutrition Medicine medicine.symptom hormones hormone substitutes and hormone antagonists Research Article Signal Transduction medicine.medical_specialty Histology Neurophysiology [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Diet High-Fat 03 medical and health sciences Model Organisms Arcuate nucleus Internal medicine medicine Animals Food and Nutrition Obesity 030304 developmental biology Nutrition Cell Proliferation Cell growth [ SDV.BC ] Life Sciences [q-bio]/Cellular Biology lcsh:R Arcuate Nucleus of Hypothalamus Neurosciences Neuroendocrinology medicine.disease Disease Models Animal Astrocytes Neurons and Cognition Anorectic lcsh:Q Molecular Neuroscience Physiological Processes Energy Metabolism Weight gain 030217 neurology & neurosurgery Homeostasis Neuroscience |
| Zdroj: | Plos One 8 (8), e72029. (2013) PLoS ONE, Vol 8, Iss 8, p e72029 (2013) PLoS ONE PLoS ONE, Public Library of Science, 2013, 8 (8), pp.e72029. 〈10.1371/journal.pone.0072029〉 PLoS ONE, Public Library of Science, 2013, 8 (8), pp.e72029. ⟨10.1371/journal.pone.0072029⟩ www.plosone.org/ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0072029〉 |
| Popis: | International audience; The hypothalamus plays a crucial role in the control of the energy balance and also retains neurogenic potential into adulthood. Recent studies have reported the severe alteration of the cell turn-over in the hypothalamus of obese animals and it has been proposed that a neurogenic deficiency in the hypothalamus could be involved in the development of obesity. To explore this possibility, we examined hypothalamic cell renewal during the homeostatic response to dietary fat in mice, i.e., at the onset of diet-induced obesity. We found that switching to high-fat diet (HFD) accelerated cell renewal in the hypothalamus through a local, rapid and transient increase in cell proliferation, peaking three days after introducing the HFD. Blocking HFD-induced cell proliferation by central delivery of an antimitotic drug prevented the food intake normalization observed after HFD introduction and accelerated the onset of obesity. This result showed that HFD-induced dividing brain cells supported an adaptive anorectic function. In addition, we found that the percentage of newly generated neurons adopting a POMC-phenotype in the arcuate nucleus was increased by HFD. This observation suggested that the maturation of neurons in feeding circuits was nutritionally regulated to adjust future energy intake. Taken together, these results showed that adult cerebral cell renewal was remarkably responsive to nutritional conditions. This constituted a physiological trait required to prevent severe weight gain under HFD. Hence this report highlighted the amazing plasticity of feeding circuits and brought new insights into our understanding of the nutritional regulation of the energy balance. |
| Databáze: | OpenAIRE |
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