The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis
| Autor: | Nihal Büyükuslu, Cüneyd Parlayan, Havvanur Yoldaş Ilktaç |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Probiotics Inflammatory Bowel Disease Experimental colitis medicine.disease Colitis Food Science and Technology Inflammatory bowel disease Omega Gastroenterology Gıda Bilimi ve Teknolojisi Internal medicine Polyamines Medicine Omega-3 Fatty Acids business Colitis Inflammatory bowel disease Omega-3 fatty acids Probiotics Polyamines |
| Zdroj: | Volume: 7, Issue: 4 279-285 Food and Health |
| ISSN: | 2602-2834 |
| Popis: | Polyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine the effects of probiotics and omega 3 fatty acids on serum polyamine levels in colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, colitis treated by probiotics (VSL#3), colitis treated by omega-3, and colitis treated by both probiotics and omega-3. Experimental colitis was induced by injection of 200 mg/kg 2,4-Dinitrobenzenesulfonic acid (DNBS). The probiotic and the omega-3 fatty acid supplements were applied daily by oral gavage. Serum polyamine levels were measured with high performance liquid chromatography (HPLC). In each group, the levels of serum polyamines are the highest in spermidine and the least in spermine. Bowel inflammation in experimentally induced colitis mice resulted in lower serum polyamine concentrations. In probiotic and omega 3 fatty acid supplemented group significant decreases were observed for spermine and spermidine (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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