High mobility group box 1 and markers of oxidative stress in human cord blood
| Autor: | Sara Manti, Eloisa Gitto, Giovanni Corsello, Edoardo Spina, Russel J. Reiter, Angela Alibrandi, Raffaele Falsaperla, Carmelo Salpietro, Roberta Granese, Antonella Palmara, Maria Angela La Rosa, Lucia Marseglia, Gabriella D'Angelo, Pietro Impellizzeri |
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| Přispěvatelé: | D'Angelo G, Granese R, Marseglia L, Impellizzeri P, Alibrandi A, Palmara A, La Rosa MA, Manti S, Salpietro C, Spina E, Reiter RJ, Falsaperla R, Corsello G, Gitto E. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cord
Physiology 030204 cardiovascular system & hematology HMGB1 medicine.disease_cause Umbilical cord Umbilical vein Antioxidants 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Medicine Humans HMGB1 Protein Labor Obstetric biology business.industry Infant Newborn Cord blood high mobility group box 1 newborn oxidative stress pregnancy cord blood high mobility group box 1 newborn oxidative stress pregnancy Venous blood medicine.disease Delivery Obstetric Fetal Blood Oxidative Stress medicine.anatomical_structure Italy Cord blood Pediatrics Perinatology and Child Health biology.protein Female business Reactive Oxygen Species Oxidative stress Biomarkers |
| Popis: | Background Parturition induces considerable oxidative stress and many inflammatory mediators, such as high mobility group box 1 (HMGB1), are involved from the beginning of the pregnancy to birth. The aim of the present study was to evaluate serum cord blood concentration of diacron-reactive oxygen metabolites (d-ROM), biological antioxidant potential (BAP), and HMGB1 to investigate the perinatal oxidative status of neonates and correlation with mode of delivery, as well as the influence of labor. Methods The subjects consisted of 214 neonates delivered at University Hospital "G. Martino", Messina, in a 6 months period. Venous blood samples were collected from the umbilical cord after cord separation. Results Umbilical cord venous blood HMGB1 was significantly higher in the spontaneous vaginal delivery (SVD) group than in the elective or emergency cesarean section (CS) group (P = 0.018). Regarding labor, there was no significant difference in HMGB1 concentration in umbilical vein blood between the spontaneous and induced labor groups (P = 0.250). Furthermore, d-ROM was significantly different between the SVD group and the elective or emergency CS group (P = 0.044). BAP concentration, however, was not significantly different, not even with regard to mode of labor. Conclusion Oxidation is higher in newborns delivered by SVD than in those delivered by CS, and HMGB1 may be involved in the mechanisms of birth, and responsible for decidual modifications that lead to birth. |
| Databáze: | OpenAIRE |
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