Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy
| Autor: | Mado Berra, Nicolas Martin-Silva, Hubert de Boysson, Guillaume Martin-Blondel, Maxime Faisant, Luc Fournier, Jacques Gasnault, Alexandra Audemard-Verger, Achille Aouba, Alexis Ruet, G. Maigné, Astrid Vabret, Françoise Chapon, Marie-Catherine Besse, Jonathan Boutemy |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cell JC virus Salvage therapy immune checkpoint inhibitor medicine.disease_cause progressive multifocal leukoencephalopathy Virus 03 medical and health sciences 0302 clinical medicine Immune system PD-1 medicine 030212 general & internal medicine nivolumab medicine.diagnostic_test business.industry Brain biopsy Progressive multifocal leukoencephalopathy medicine.disease Editor's Choice 030104 developmental biology Infectious Diseases medicine.anatomical_structure Oncology Brief Reports Nivolumab business |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| Popis: | In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape. PD-1 and its ligand are pivotal in the T-cell-exhaustion pathway involved in viral infections. In this paper, we report a complete response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of brain biopsy suggest that PD-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape. |
| Databáze: | OpenAIRE |
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