Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease
| Autor: | Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Douwe E. Atsma, Cornelis H. Slump, Alina van de Burgt, Arthur J.H.A. Scholte, Floris H. P. van Velden |
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| Přispěvatelé: | Digital Society Institute, Robotics and Mechatronics, Biomedical Photonic Imaging |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Experimental validation
Biomedical Engineering R895-920 chemistry.chemical_element Standardized uptake value Phantom study Iterative reconstruction 030204 cardiovascular system & hematology Single-photon emission computed tomography Technetium Coronary artery disease Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine medicine Quantitative SPECT Radiology Nuclear Medicine and imaging Instrumentation Original Research Radiation medicine.diagnostic_test business.industry 99mTc-tetrofosmin Tc-tetrofosmin Repeatability SPECT/CT Torso medicine.disease medicine.anatomical_structure chemistry SPECT Tc-99m-tetrofosmin Nuclear medicine business CT |
| Zdroj: | EJNMMI Physics, Vol 8, Iss 1, Pp 1-13 (2021) EJNMMI physics, 8(1):48. Springer EJNMMI Physics, 8(1). SPRINGER EJNMMI Physics |
| ISSN: | 2197-7364 |
| Popis: | Myocardial perfusion scintigraphy (MPS) is based on visual qualitative interpretation and hence interobserver variability might affect clinical decision-making for the patient. Quantification of single photon emission computed tomography (SPECT) imaging enables absolute measurement of treatment efficacy. The aim of this experimental study is to assess quantitative accuracy and precision of iterative image reconstruction (Evolution; Q.Metrix package; GE Healthcare, Little Chalfont, UK), making use of both phantom and patient studies, for potential application of 99mTc-tetrofosmin SPECT/CT in coronary artery disease (CAD) patients. This research consists of a phantom study and an experimental validation study with patient data. An anthropomorphic torso phantom with cardiac insert was filled with technetium (99mTc) and acquired on a SPECT/CT gamma (Discovery 670 Pro; GE Healthcare). Seven sets of 6 acquisitions were evaluated containing a cardiac insert with various defect sizes and configurations. Subsequently, volumes‐of‐interest of the defects were manually drawn on CT to assess the recovery coefficient (RC). Bull’s eye plots were composed to evaluate the uptake per segment. Finally, 99mTc-tetrofosmin SPECT/CT scans were collected retrospectively in ten CAD patients after bone marrow cell treatment and evaluated using Evolution. The phantom study shows that the activity concentration converged after seven iterations (ten subsets) using Evolution. SPECT/CT data were reconstructed with and without Butterworth post-filtering. The average repeatability deviation of all configurations was 2.66% and 2.90% (%SD mean) for the filtered and unfiltered data, respectively. The accuracy after Butterworth post-filtering was lower compared to the unfiltered data with a mean(SD) RC of 0.66 ± 0.06 and 0.71 ± 0.05, respectively (p |
| Databáze: | OpenAIRE |
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