Induction of hepatic drug metabolizing enzymes and interaction with carbon tetrachloride in rats after a single oral exposure to atrazine
| Autor: | Mauro Dacasto, Gerben A.E. van 't Klooster, Anita Bosio, Carlo Nebbia, Elisa Burdino, G. Ugazio |
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| Rok vydání: | 1993 |
| Předmět: |
Male
LIVER Cytochrome PROTEINS CYTOCHROME-P-450 3-METHYLCHOLANTHRENE PENTOXYRESORUFIN ETHOXYRESORUFIN CONTAMINATION DEALKYLATION ASSAY Pharmacology Toxicology chemistry.chemical_compound Cytochrome P-450 Enzyme System herbicide In vivo Oral administration Cytochrome P-450 CYP1A1 Animals drug metabolizing enzymes Inducer Atrazine Rats Wistar Enzyme inducer induction chemistry.chemical_classification biology General Medicine atrazine carbon tetrachloride Glutathione Rats Enzyme chemistry Biochemistry Enzyme Induction Phenobarbital Cytochrome P-450 CYP2B1 biology.protein Carbon tetrachloride Oxidoreductases |
| Zdroj: | Toxicology Letters. 69:279-288 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(93)90033-t |
| Popis: | A single oral dose (430 mg/kg) of atrazine, a widely employed s-triazine herbicide, was administered to young male rats. There was a significant increase of the in vivo elimination ofhexobarbital and a significant induction of the activity of 7-pentoxyresorufin-O-dealkylase, while cytochrome P-450 content and other mixed function oxidase activities remained unaltered. The administration of carbon tetrachloride (CCI,) to atrazine pretreated rats did not substantially augment the impairment of drug metabolizing enzymes brought about by CCLi alone. Results suggest that atrazine behaves like a relatively weak inducer of phenobarbital-inducible families of cytochrome P-450. |
| Databáze: | OpenAIRE |
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