Immunoregulatory Changes in Kawasaki Disease
| Autor: | Janine Jason, A Han, A Hu, I Tham, A Eick, R Campbell, L Gregg, K.L Inge |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Cellular immunity medicine.medical_specialty Time Factors T-Lymphocytes media_common.quotation_subject Antigens CD19 Immunology Receptors Antigen T-Cell Mucocutaneous Lymph Node Syndrome Gastroenterology Pathology and Forensic Medicine Pathogenesis Antigens CD hemic and lymphatic diseases Internal medicine Immunopathology Receptors Transferrin medicine Humans Immunology and Allergy IL-2 receptor Child media_common Vascular disease business.industry Integrin beta1 Convalescence Immunoglobulins Intravenous Infant Receptors Interleukin-2 Gamma globulin medicine.disease Antigens Differentiation B-Lymphocyte Child Preschool Female Kawasaki disease Blast Crisis business Biomarkers |
| Zdroj: | Clinical Immunology and Immunopathology. 84:296-306 |
| ISSN: | 0090-1229 |
| DOI: | 10.1006/clin.1997.4376 |
| Popis: | Kawasaki disease (KD) is an acute vasculitis of unknown etiology, occurring in young children and treated with intravenous gamma globulin (IVIG) to prevent significant cardiac morbidity and mortality. We studied KD patients pre- and post-IVIG therapy and at >40 days posttherapy, additionally comparing them with matched pediatric control patients and parents. Using three-color flow cytometry, we examined immune changes in KD, especially previously unassessed markers of T-lymphocyte activation, memory, and adhesion. The percentage of cells positive for CD19, CD25, CD38, and CD71 was significantly lower during convalescence compared with pre-IVIG (medians: CD19, 18% vs 26%, P = 0.0004; CD25, 6% vs 9% for CD3(+) cells, P = 0.0074; CD38, 78% vs 89% for CD8(+) cells, P = 0.0015; CD71, 1% vs 6% for CD4(+) cells, P = 0.0024). The proportion of CD3(+) cells increased (medians: CD3, 66% vs 45%, P < 0.0001). Values for all parameters varied greatly pre- and post-IVIG, but not in a consistent direction. The sole patient with cardiac abnormalities had the greatest pre-/post-IVIG variability. These changes support the involvement of T-lymphocytes in the acute KD vasculitic process. They also suggest that T-lymphocytes involved in endothelial damage during acute KD may be subsequently removed or eliminated from the peripheral blood. |
| Databáze: | OpenAIRE |
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