Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice
| Autor: | Ming-Der Chen, Paul S. Alexander, Vivian C. Yang, Shy-Jane Liou, Wen-Han Lin, Pi-Yao Lin |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Mice Obese Zinc Biochemistry Inorganic Chemistry Mice Internal medicine medicine Adipocytes Lipolysis Animals Insulin Obesity Glycemic Glucose tolerance test medicine.diagnostic_test Chemistry Biochemistry (medical) General Medicine Glucose Tolerance Test medicine.disease Lipid Metabolism In vitro Mice Inbred C57BL Endocrinology Lipogenesis |
| Zdroj: | Biological trace element research. 61(3) |
| ISSN: | 0163-4984 |
| Popis: | The effects of zinc supplementation (20 mM ZnCl2 from the drinking water for eight weeks) on plasma glucose and insulin levels, as well as its in vitro effect on lipogenesis and lipolysis in adipocytes were studied in genetically obese (ob/ob) mice and their lean controls (+/?). Zinc supplementation reduced the fasting plasma glucose levels in both obese and lean mice by 21 and 25%, respectively (p < 0.05). Fasting plasma insulin levels were significantly decreased by 42% in obese mice after zinc treatment. In obese mice, zinc supplementation also attenuated the glycemic response by 34% after the glucose load. The insulin-like effect of zinc on lipogenesis in adipocytes was significantly increased by 80% in lean mice. However, the increment of 74% on lipogenesis in obese mice was observed only when the zinc plus insulin treatment was given. This study reveals that zinc supplementation alleviated the hyperglycemia of ob/ob mice, which may be related to its effect on the enhancement of insulin activity. |
| Databáze: | OpenAIRE |
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