Possibility of usage of aminostigmine structural analogue for the treatment of toxic cognitive disorders
| Autor: | S. N. Subbotina, A. F. Kurpyakova, M. A. Tyunin, I. V. Fateev |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Carbamate medicine.medical_treatment Amnesia Pharmacology General Biochemistry Genetics and Molecular Biology Oxalate Lethal Dose 50 chemistry.chemical_compound Aminostigmine medicine Memory formation Galantamine Animals Cholinesterase biology Ipidacrine General Medicine Rats chemistry biology.protein Carbamates medicine.symptom Cognition Disorders Neuroscience medicine.drug Pyridostigmine Bromide |
| Zdroj: | Bulletin of experimental biology and medicine. 156(3) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effects of 2-(hexyl(methyl)amino)methyl)pyridyl-3-dimethyl carbamate (OPDC), a structural analogue of aminostigmine oxalate, on memory formation in rats with toxic scopolamine-induced amnesia. It was shown that OPDC in non-toxic doses ((1)/215 LD50) has significant anti-amnesic action. Ipidacrine and galantamine in the doses similar to toxic doses ((1)/17 and (1)/6 of LD50, respectively) induced the retention of memory trace. Administration of aminostigmine ((1)/11 of LD50) induced unstable anti-amnesic effect in the model of scopolamine-induced amnesia. |
| Databáze: | OpenAIRE |
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