Active dynamics of tissue shear flow
| Autor: | Popović, Marko, Nandi, Amitabha, Merkel, Matthias, Etournay, Raphael, Eaton, Suzanne, Jülicher, Frank, Salbreux, Guillaume |
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| Přispěvatelé: | Max Planck Institute for the Physics of Complex Systems (MPI-PKS), Max-Planck-Gesellschaft, Indian Institute of Technology Bombay (IIT Bombay), Syracuse University, Institut Pasteur [Paris], Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), The Francis Crick Institute [London], MP, AN, MM, FJ and GS acknowledge funding by the Max-Planck-Gesellschaft. RE acknowledges a Marie Curie fellowship from the EU 7th Framework Programme (FP7). SE acknowledge funding from the ERC. MP, MM, SE and FJ acknowledge funding by Bundesministerium für Bildung und Forschung. MM also acknowledges funding from the Alfred P Sloan Foundation, the Gordon and Betty Moore Foundation, and NSF-DMR-1352184. GS acknowledges support by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001317), the UK Medical Research Council (FC001317), and the Wellcome Trust (FC001317). AN acknowledges Industrial Research & Consultancy Centre at IIT Bombay for financial support., Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
FOS: Physical sciences
[SDV.BC]Life Sciences [q-bio]/Cellular Biology Mechanics Planar Polarity Wing Epithelium Extension Cell Behavior (q-bio.CB) Morphogenesis biological physics [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] Physics - Biological Physics Tissues and Organs (q-bio.TO) [SDV.BDD]Life Sciences [q-bio]/Development Biology Migration Shape Quantitative Biology - Tissues and Organs [PHYS.MECA]Physics [physics]/Mechanics [physics] [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Living matter Biological Physics (physics.bio-ph) Rearranging Disordered Patterns tissue mechanics FOS: Biological sciences hydrodynamics Quantitative Biology - Cell Behavior Drosophila rheology active matter [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft] Cell Intercalation |
| Zdroj: | New Journal of Physics New Journal of Physics, Institute of Physics: Open Access Journals, 2017, 19 (3), pp.033006. ⟨10.1088/1367-2630/aa5756⟩ New Journal of Physics, 2017, 19 (3), pp.033006. ⟨10.1088/1367-2630/aa5756⟩ |
| ISSN: | 1367-2630 |
| DOI: | 10.1088/1367-2630/aa5756⟩ |
| Popis: | International audience; We present a hydrodynamic theory to describe shear flows in developing epithelial tissues. We introduce hydrodynamic fields corresponding to state properties of constituent cells as well as a contribution to overall tissue shear flow due to rearrangements in cell network topology. We then construct a generic linear constitutive equation for the shear rate due to topological rearrangements and we investigate a novel rheological behaviour resulting from memory effects in the tissue. We identify two distinct active cellular processes: generation of active stress in the tissue, and actively driven topological rearrangements. We find that these two active processes can produce distinct cellular and tissue shape changes, depending on boundary conditions applied on the tissue. Our findings have consequences for the understanding of tissue morphogenesis during development. |
| Databáze: | OpenAIRE |
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