Administration of Lactobacillus plantarum Lp62 to dam rats at the end of delivery and during lactation affects TGF-β1 level and nutritional milk composition, and body weight of pups
| Autor: | Érika Pereira De Souza, Mariluze Peixoto Cruz, Raquel Passos Rezende, Ana Paula Trovatti Uetanabaro, Marina Lima dos Anjos, Thainara Barros da Rocha, Aracely Vieira de Melo, Dhaísa Cristhina Alves Silva, Mara Viana Silva, Regiane Yatsuda, Ana Marques Botelho, Beatriz Manuela Silva Santos, Gabriel Vinderola, Patrícia Prado Santos, Carla Cristina Romano, Nayonara Santana Aguiar, Gladistone Correia Messias, Erika Santos Porto, Manoela Rios Trindade Carneiro, Ana Marta Novais Rocha, Rayra Almeida Sousa, Lucas Miranda Marques |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Administration Oral IMMUNOLOGY law.invention chemistry.chemical_compound Probiotic fluids and secretions 0302 clinical medicine MILK Oral administration law Pregnancy Lactation Food science Lactose Nutrition and Dietetics biology PROBIOTIC PUPS food and beverages Lactic acid Animals Suckling medicine.anatomical_structure Models Animal Female CIENCIAS NATURALES Y EXACTAS Otras Ciencias Biológicas 030209 endocrinology & metabolism RATS Transforming Growth Factor beta1 Ciencias Biológicas 03 medical and health sciences medicine Animals Rats Wistar 030109 nutrition & dietetics Cholesterol Body Weight LACTOBACILLUS PLANTARUM medicine.disease biology.organism_classification Rats chemistry Animals Newborn Pregnancy Animal Lactobacillus plantarum |
| DOI: | 10.1007/s00394-018-1628-y |
| Popis: | Purpose: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat’s pups; on yield, cytokines and milk composition was studied. Methods: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans. It was administered daily by gavage to Wistar rats (n = 8), from the 7th day before delivery and for 20 days during lactation, in a concentration of 1.44 × 10 9 CFU/rat. The dam and pups were weighed and milk was collected at 12th and 19th day for determination of protein, triglycerides, cholesterol and lactose by colorimetric assays. TGF-β1 milk levels were analyzed by ELISA. The mammary glands of rats were removed for histological analysis. To detect statistical differences between the groups, tests of mean differences at a significance level of 5% was performed. Results: Supplementation with L. plantarum L62 resulted in significant higher weight of pups (p < 0.05), with similar weight on dams (p > 0.05). The milk yield was not altered by L. plantarum treatment, but the levels of protein, triglycerides and cholesterol were increased (p < 0.05), with no difference in lactose concentration (p > 0.05). Levels of TGF-β1 were higher in the milk of L. plantarum treatment (p < 0.05). Conclusions: The treatment of dams at the end of pregnancy and lactation with L. plantarum Lp62 increased nutritional content of milk, probably contributing to the higher weight of the pups. The higher levels of TGF-β1 in the milk, could promote immune benefits to the pups. Further studies in this field are needed to prove the potential use of L. plantarum Lp62 as a probiotic. Fil: Messias, Gladistone Correia. Universidade Federal da Bahia; Brasil Fil: Rocha, Ana Marta Novais. Universidade Federal da Bahia; Brasil Fil: Santos, Beatriz Manuela Silva. Universidade Federal da Bahia; Brasil Fil: Botelho, Ana Marques. Universidade Federal da Bahia; Brasil Fil: Silva, Dhaísa Cristhina Alves. Universidade Federal da Bahia; Brasil Fil: Porto, Erika Santos. Universidade Federal da Bahia; Brasil Fil: dos Anjos, Marina Lima. Universidade Federal da Bahia; Brasil Fil: Sousa, Rayra Almeida. Universidade Federal da Bahia; Brasil Fil: Silva, Mara Viana. Universidade Federal da Bahia; Brasil Fil: da Rocha, Thainara Barros. Universidade Federal da Bahia; Brasil Fil: de Melo, Aracely Vieira. Universidade Federal da Bahia; Brasil Fil: Carneiro, Manoela Rios Trindade. Universidade Federal da Bahia; Brasil Fil: Aguiar, Nayonara Santana. Universidade Federal da Bahia; Brasil Fil: Santos, Patrícia Prado. Universidade Federal da Bahia; Brasil Fil: de Souza, Erika Pereira. Universidade Federal da Bahia; Brasil Fil: Cruz, Mariluze Peixoto. Universidade Federal da Bahia; Brasil Fil: Marques, Lucas Miranda. Universidade Federal da Bahia; Brasil Fil: Rezende, Raquel Passos. Universidade Federal da Bahia; Brasil. Universidade Estadual de Santa Cruz; Brasil Fil: Romano, Carla Cristina. Universidade Federal da Bahia; Brasil. Universidade Estadual de Santa Cruz; Brasil Fil: Uetanabaro, Ana Paula. Universidade Estadual de Santa Cruz; Brasil Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Yatsuda, Regiane. Universidade Federal Da Bahia; Brasil |
| Databáze: | OpenAIRE |
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