Cyanide Antidotes for Mass Casualties: Water-Soluble Salts of the Dithiane (Sulfanegen) from 3-Mercaptopyruvate for Intramuscular Administration
| Autor: | Alexandre R. Monteil, Daune L. Crankshaw, Robert Vince, Steven E. Patterson, Herbert T. Nagasawa, Jonathan F. Cohen |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_treatment
Cyanide Antidotes Pharmacology Injections Intramuscular Article Toxicology chemistry.chemical_compound 3-mercaptopyruvate Drug Discovery medicine Humans Mass Casualty Incidents Cysteine Antidote Dithiane Sulfanegen Cyanides Sulfur Compounds Poisoning Mass Casualty Water soluble chemistry Molecular Medicine Salts Quinolizines CYANIDE ANTIDOTES |
| Zdroj: | Journal of Medicinal Chemistry. 56:1346-1349 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm301633x |
| Popis: | Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote. |
| Databáze: | OpenAIRE |
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