Glomerulopathy in patient with Donohue syndrome (leprechaunism)
| Autor: | Stephen F. Kemp, M J Elders, Eileen N. Ellis, Frindik Jp |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Adolescent Endocrinology Diabetes and Metabolism Developmental Disabilities Kidney Glomerulus Urology urologic and male genital diseases Basement Membrane Renal Circulation Diabetic nephropathy Glomerulopathy Internal medicine Internal Medicine medicine Humans Child Advanced and Specialized Nursing Kidney medicine.diagnostic_test business.industry Glomerular basement membrane Glomerular mesangium Glomerulonephritis Syndrome medicine.disease Capillaries Glomerular Mesangium medicine.anatomical_structure Endocrinology Hypertension Female Renal biopsy Donohue syndrome Insulin Resistance business |
| Zdroj: | Diabetes care. 14(5) |
| ISSN: | 0149-5992 |
| Popis: | Objective To evaluate renal structure in a child with Donohue syndrome (leprechaunism), who at 10 yr of age was noted to have hypertension, microalbuminuria, and enlarged kidneys, a renal biopsy was performed. Research Design And Methods The renal biopsy tissue was evaluated by light and electron microscopy with standard stereological techniques to measure glomerular volume, glomerular basement membrane width, fractional mesangial volume, and peripheral capillary filtering surface density. Results On renal biopsy, there was a marked increase in glomerular volume, glomerular basement width, and mesangial volume, findings similar to those seen in patients with diabetic nephropathy. Conclusions This patient with marked insulin resistance associated with Donohue syndrome demonstrates renal and glomerular enlargement and morphometric glomerular changes similar to those seen in patients with diabetic nephropathy. In unusual syndromes with hyperglycemia and hyperinsulinemia, renal structural and functional changes typical of traditional diabetes mellitus may be seen. |
| Databáze: | OpenAIRE |
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