High-sensitive fluorescence endoscope using electrocardiograph-synchronized multiple exposure
| Autor: | Etsuko Kobayashi, Hongen Liao, Takehiro Ando, Sanghyun Joung, Ichiro Sakuma, Shunei Kyo, Kazuhiro Taniguchi, Hongho Kim |
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| Rok vydání: | 2010 |
| Předmět: |
Multiple exposure
medicine.medical_specialty Endoscope Swine Myocardial Ischemia Biomedical Engineering Endoscopic surgery Health Informatics High sensitive Fluorescence Electrocardiography Image Processing Computer-Assisted medicine Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Endoscopes business.industry Reproducibility of Results Equipment Design General Medicine Computer Graphics and Computer-Aided Design Computer Science Applications Highly sensitive Disease Models Animal Female Surgery Computer Vision and Pattern Recognition Radiology Ischemic heart business Biomedical engineering |
| Zdroj: | International Journal of Computer Assisted Radiology and Surgery. 6:73-81 |
| ISSN: | 1861-6429 1861-6410 |
| DOI: | 10.1007/s11548-010-0478-8 |
| Popis: | Fluorescence-based measurement of cardiac disease, using autofluorescent substances that already exist in the heart, has not been used for endoscopic surgery because the endoscopic lenses cannot transmit sufficient light. A highly sensitive fluorescence endoscope using an electrocardiograph (ECG)-synchronized multiple exposure (ESME) approach was developed that provides a bright fluorescent image.A system was developed consisting of an endoscope, an excitation light, an ECG amplifier, a trigger and delay unit, and a computer. This system is based on periodic motion of the heart. Since the shape of the heart can be photographed by ECG triggering in a similar manner, a bright image can be synthesized by accumulating multiple trigger-captured images. Laboratory and in vivo experiments were performed to confirm the effectiveness of ESME.The experimental results revealed that the trigger unit generated the synchronization signals required to produce high-quality images of the heart depending on heart rate. The difference among trigger-captured images from the actual organ, which affects the quality of ESME images, was estimated at 0.65 mm from the calculated displacement of a marker on the heart. The results also revealed that a bright fluorescent image can be captured by ESME.A highly sensitive fluorescence endoscope using ESME was developed and successfully tested. The experimental results indicated that the method enabled high-quality image acquisition in a very low illumination environment. This system is effective for the observation of faint fluorescence in the heart and is useful for the intraoperative examination of the heart status. |
| Databáze: | OpenAIRE |
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