Pellicle formation in the malaria parasite
| Autor: | Dorothee Heincke, Louisa Wilcke, Susann Herrmann, Tim W. Gilberger, Tobias Spielmann, Caroline Bruns, Maya Kono, Tatianna Wai Ying Wong |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell division Plasmodium falciparum Schizonts Short Report Protozoan Proteins Biology Bioinformatics Schizogony Cell membrane 03 medical and health sciences Basal complex medicine Humans Cells Cultured Inner membrane complex Cell Membrane Membrane Proteins Cell Biology Transmembrane protein Malaria 3. Good health Cell biology Transport protein Protein Transport 030104 developmental biology medicine.anatomical_structure Membrane protein Apicomplexa Plasma membrane invagination Plasma membrane |
| Zdroj: | Journal of Cell Science |
| ISSN: | 1477-9137 0021-9533 |
| Popis: | The intraerythrocytic developmental cycle of Plasmodium falciparum is completed with the release of up to 32 invasive daughter cells, the merozoites, into the blood stream. Before release, the final step of merozoite development is the assembly of the cortical pellicle, a multi-layered membrane structure. This unique apicomplexan feature includes the inner membrane complex (IMC) and the parasite's plasma membrane. A dynamic ring structure, referred to as the basal complex, is part of the IMC and helps to divide organelles and abscises in the maturing daughter cells. Here, we analyze the dynamics of the basal complex of P. falciparum. We report on a novel transmembrane protein of the basal complex termed BTP1, which is specific to the genus Plasmodium. It colocalizes with the known basal complex marker protein MORN1 and shows distinct dynamics as well as localization when compared to other IMC proteins during schizogony. Using a parasite plasma membrane marker cell line, we correlate dynamics of the basal complex with the acquisition of the maternal membrane. We show that plasma membrane invagination and IMC propagation are interlinked during the final steps of cell division. Summary: We newly identify a Plasmodium-specific transmembrane protein of the basal complex termed BTP1. BTP1 dynamics during schizogony correlate with membrane invagination during the final steps of cell division. |
| Databáze: | OpenAIRE |
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