HARMFUL AND PROTECTIVE ROLES OF NEUTROPHILS IN SEPSIS
| Autor: | Eric W. Olle, J. Vidya Sarma, Peter A. Ward, Hongwei Gao, Laszlo M. Hoesel, John G. Younger, Thomas A. Neff, Simona B Neff, Kurt D. Bernacki, Matthew J. Pianko |
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| Rok vydání: | 2005 |
| Předmět: |
Resuscitation
Neutropenia Time Factors Neutrophils Multiple Organ Failure Neutrophile Kidney Critical Care and Intensive Care Medicine Sepsis Mice Intensive care Animals Medicine Peroxidase Innate immune system business.industry Organ dysfunction bacterial infections and mycoses medicine.disease Rats Liver Organ Specificity Immunoglobulin G Bacteremia Immunology Emergency Medicine medicine.symptom business |
| Zdroj: | Shock. 24:40-47 |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/01.shk.0000170353.80318.d5 |
| Popis: | The current studies demonstrate protective and harmful effects of neutrophils (PMN) during experimental sepsis after cecal ligation and puncture (CLP). It is known that CLP induces signaling defects in blood PMN. When PMN were depleted 12 h after CLP, there were dramatic reductions in levels of bacteremia, evidence for reduced liver and renal dysfunction, sharp reductions in serum levels of cytokines (IL-1beta, IL-6, IL-10, TNF-alpha, and IL-2), and improved survival. In contrast, PMN depletion before CLP resulted in substantial increases in bacteremia and no evidence for attenuation of liver and renal failure dysfunction. These data suggest that at the onset of sepsis, PMN are important in regulating the levels of bacteremia, whereas after the onset of sepsis, as they lose innate immune functions, their presence is associated with higher levels of bacteremia and intensified organ dysfunction. |
| Databáze: | OpenAIRE |
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