Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome
| Autor: | Bettina Bidmon, N. Cairns, Rainer Seidl, Susanne Fang-Kircher, Gert Lubec |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Brain Chemistry medicine.medical_specialty Cerebellum Pathology Programmed cell death General Neuroscience Neurodegeneration Apoptosis Biology medicine.disease Fas receptor medicine.anatomical_structure Endocrinology Frontal lobe Downregulation and upregulation Cerebral cortex Internal medicine medicine Humans fas Receptor Down Syndrome Tumor Suppressor Protein p53 |
| Zdroj: | Neuroscience Letters. 260:9-12 |
| ISSN: | 0304-3940 |
| Popis: | In Down syndrome (DS), enhanced apoptosis (programmed cell death) may play a role in the pathogenesis of characteristic mental retardation and precocious dementia of Alzheimer-type. Upregulation of p53 and APO-1/Fas (CD95) precedes apoptosis in many cell types, and a potential role for these molecules has already been demonstrated in Alzheimer's disease (AD) and several other neurodegenerative diseases. We measured p53 and APO-1/Fas (CD95) protein in four different regions of cerebral cortex and cerebellum in nine adult DS patients with Alzheimer-like neuropathologic lesions compared to nine controls. Quantitative ELISA demonstrated higher frontal lobe (mean+/-SD: 0.10+0.035 vs. 0.041+/-0.016 ng/mg protein), temporal lobe (0.062+/-0.021 vs. 0.032+/-0.019 ng/mg protein) and cerebellar levels (0.078+/-0.030 vs. 0.039+/-0.032 ng/mg protein) of p53 protein, and higher temporal lobe (mean+/-SD: 12.3+/-4.3 vs. 5.3+/-2.0 U/mg protein) and cerebellar levels (5.9+/-1.4 vs. 2.9+/-1.1 U/mg protein) of APO-1/Fas (CD95) protein. The results suggest that p53- or APO-1/Fas (CD95)-associated apoptosis may be an important feature of neurodegeneration in DS. |
| Databáze: | OpenAIRE |
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