Immune cell function assay does not identify biopsy-proven pediatric renal allograft rejection or infection

Autor:	Paul C. Grimm, Abanti Chaudhuri, C. M. Ryan, Waldo Concepcion
Rok vydání:	2014
Předmět:	CD4-Positive T-Lymphocytes Graft Rejection Male Adolescent Opportunistic infection medicine.medical_treatment Biopsy Opportunistic Infections Kidney chemistry.chemical_compound Leukocyte Count Young Adult Immune system Adenosine Triphosphate Medicine Humans Immune Cell Function Assay Renal Insufficiency Viremia Child Retrospective Studies Immunosuppression Therapy Transplantation Creatinine business.industry Graft Survival Infant Immunosuppression medicine.disease Allografts Kidney Transplantation Immunosuppressive drug medicine.anatomical_structure chemistry Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Immunosuppressive Agents
Zdroj:	Pediatric transplantation. 18(5)
ISSN:	1399-3046
Popis:	Management of pediatric renal transplant patients involves multifactorial monitoring modalities to ensure allograft survival and prevent opportunistic infection secondary to immunosuppression. An ICFA, which utilizes CD4 T-cell production of ATP to assess immune system status, has been used to monitor transplant recipients and predict susceptibility of patients to rejection or infection. However, the validity of this assay to reflect immune status remains unanswered. In a two-yr retrospective study that included 31 pediatric renal transplant recipients, 42 patient blood samples were analyzed for immune cell function levels, creatinine, WBC (white blood cell) count, immunosuppressive drug levels, and viremia, concurrent with renal biopsy. T-cell ATP production as assessed by ICFA levels did not correlate with allograft rejection or with the presence or absence of viremia. ICFA levels did not correlate with serum creatinine or immunosuppressive drug levels, but did correlate with WBC count. The ICFA is unreliable in its ability to reflect immune system status in pediatric renal transplantation. Further investigation is necessary to develop methods that will accurately predict susceptibility of pediatric renal transplant recipients to allograft rejection and infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681dca251e5dc0525485422eefee0de3 https://pubmed.ncbi.nlm.nih.gov/25041327 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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