Trypanosoma cruzi genotyping supports a common source of infection in a school-related oral outbreak of acute Chagas disease in Venezuela
| Autor: | Reinaldo Zavala-Jaspe, Teresa Abate, Zoraida Díaz-Bello, María del Carmen Thomas, B. Alarcón de Noya, Manuel Carlos López, Oscar Noya |
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| Rok vydání: | 2013 |
| Předmět: |
Chagas disease
Genotype Genotyping Techniques Epidemiology Trypanosoma cruzi Genes Protozoan Molecular Sequence Data Biology Disease Outbreaks Beverages Intergenic region parasitic diseases medicine Animals Humans Chagas Disease Typing Genotyping Psidium Schools Base Sequence Transmission (medicine) Outbreak medicine.disease biology.organism_classification Venezuela Virology Original Papers Rats Infectious Diseases Sequence Alignment |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 |
| Popis: | SUMMARYTrypanosoma cruzi I, a discrete typing unit (DTU) found in human infections in Venezuela and other countries of the northern region of South America and in Central America, has been recently classified into five intra-DTU genotypes (Ia, Ib, Ic, Id, Ie) based on sequence polymorphisms found in the spliced leader intergenic region. In this paper we report the genotype identification of T. cruzi human isolates from one outbreak of acute orally acquired Chagas disease that occurred in a non-endemic region of Venezuela and from T. cruzi triatomine and rat isolates captured at a guava juice preparation site which was identified as the presumptive source of infection. The genotyping of all these isolates as TcId supports the view of a common source of infection in this oral Chagas disease outbreak through the ingestion of guava juice. Implications for clinical manifestations and dynamics of transmission cycles are discussed. |
| Databáze: | OpenAIRE |
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