Arginine intake is associated with oxidative stress in a general population
| Autor: | Gilka Jorge Fígaro Gattás, Regina Mara Fisberg, Ana Paula de Melo Loureiro, Dirce Maria Lobo Marchioni, Aline Martins de Carvalho, Antonio Anax Falcão de Oliveira |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Meat Arginine Endocrinology Diabetes and Metabolism Population Bioinformatics medicine.disease_cause Plant Proteins Dietary 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Malondialdehyde Linear regression medicine Humans education education.field_of_study Nutrition and Dietetics ESTRESSE OXIDATIVO business.industry Confounding Urban Health Confounding Factors Epidemiologic Glutathione Nutrition Surveys Diet Oxidative Stress 030104 developmental biology Endocrinology C-Reactive Protein Cross-Sectional Studies chemistry 030220 oncology & carcinogenesis Chronic Disease Dietary Proteins business Body mass index Oxidative stress Biomarkers Brazil |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-1244 |
| Popis: | Objective The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population-based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders. Results MDA levels were associated with meat intake ( P for linear trend = 0.031), protein from meat ( P for linear trend = 0.006), and arginine from meat ( P for linear trend = 0.044) after adjustments for confounders: age, sex, body mass index, smoking, physical activity, intake of fruit and vegetables, energy and heterocyclic amines, C-reactive protein levels, and polymorphisms in GSTM1 (glutathione S-transferase Mu 1) and GSTT1 (glutathione S-transferase theta 1) genes. Results were not significant for total protein and protein from vegetable intake ( P > 0.05). Conclusions High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age-related diseases. |
| Databáze: | OpenAIRE |
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