VEGF Gene Polymorphisms Affect Serum Protein Levels and Alter Disease Activity and Synovial Lesions in Rheumatoid Arthritis
| Autor: | Fu-Yuan Xie, Quan Yuan, Nan Yu, Zhi-Wu Yu, Jin-Ping Yi, Yu-Zhang Wu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0106 biological sciences medicine.medical_specialty Pathology Angiogenesis Arthritis Biology Polymorphism Single Nucleotide 01 natural sciences Gastroenterology Arthritis Rheumatoid Sarcoma Synovial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gene Frequency Rheumatology Clinical Research Internal medicine medicine Humans Genetic Predisposition to Disease Genetic Association Studies Demography Ultrasonography Polymorphism Genetic Synovial Membrane Case-control study General Medicine Middle Aged Joint effusion medicine.disease Vascular endothelial growth factor medicine.anatomical_structure chemistry Case-Control Studies 030220 oncology & carcinogenesis Rheumatoid arthritis Female Synovial membrane medicine.symptom 010606 plant biology & botany |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | Background Our study investigated 2 common single-nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) for their influences on serum VEGF levels, disease activity, and synovial lesions in rheumatoid arthritis (RA). Material/Methods Clinical information and venous blood samples were collected from 98 RA patients and 100 healthy controls. Genotyping on samples from the subjects was performed using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Serum VEGF levels were determined using the enzyme-linked immunosorbent assay (ELISA). The synovial thickness and joint effusion of 28 joints were measured in RA patients, and total sharp score (TSS) and disease activity score (DAS) of 28 joints were recorded. Results The genotype and allele frequencies of VEGF rs833070 (G>A) and rs3025030 (G>C) were significantly different between RA group and control group (all P |
| Databáze: | OpenAIRE |
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