Volumetric dynamic oxygen-enhanced MRI (OE-MRI): comparison with CT Brody score and lung function in cystic fibrosis patients

Autor: Christian Benden, G. J. Parker, Thomas Frauenfelder, Katharina Martini, C. M. Gygax, A. R. Morgan
Přispěvatelé: University of Zurich, Martini, K
Rok vydání: 2018
Předmět:
Adult
Lung Diseases
Male
medicine.medical_specialty
Cystic Fibrosis
610 Medicine & health
Cystic fibrosis
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
symbols.namesake
Imaging
Three-Dimensional
0302 clinical medicine
medicine
2741 Radiology
Nuclear Medicine and Imaging
Humans
Radiology
Nuclear Medicine and imaging
Lung
Neuroradiology
medicine.diagnostic_test
10042 Clinic for Diagnostic and Interventional Radiology
business.industry
Ultrasound
Magnetic resonance imaging
General Medicine
medicine.disease
Magnetic Resonance Imaging
Healthy Volunteers
Pearson product-moment correlation coefficient
Respiratory Function Tests
Oxygen
medicine.anatomical_structure
030228 respiratory system
Case-Control Studies
Coronal plane
symbols
Breathing
Female
Radiology
10178 Clinic for Pneumology
Tomography
X-Ray Computed
business
Zdroj: European Radiology. 28:4037-4047
ISSN: 1432-1084
0938-7994
DOI: 10.1007/s00330-018-5383-5
Popis: To demonstrate, in patients with cystic fibrosis (CF), the correlation between three-dimensional dynamic oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements and computed tomography Brody score (CF-CT) and lung function testing (LFT). Twenty-one patients (median age, 25 years; female, n = 8) with a range of CF lung disease and five healthy volunteers (median age, 31 years; female, n = 2) underwent OE-MRI performed on a 1.5-T MRI scanner. Coronal volumes were acquired while patients alternately breathed room air and 100% oxygen. Pre-oxygen T1 was measured. Dynamic series of T1-weighted volumes were then obtained while breathing oxygen. T1-parameter maps were generated and the following OE-MRI parameters were measured: oxygen uptake (ΔPO2max), wash-in time and wash-out time. High-resolution CT and LFT were performed. The relationship between CF-CT, LFT and OE-MRI parameters were evaluated using Pearson correlation for the whole lung and regionally. Mean CF-CT was 24.1±17.1. Mean ΔPO2max and mean wash-in as well as skewness of wash-out showed significant correlation with CF-CT (ΔPO2max: r = -0.741, p < 0.001; mean wash-in: r = 0.501, p = 0.017; skewness of wash-out: r = 0.597, p = 0.001). There was significant correlation for the whole lung and regionally between LFT parameters and OE-MR (ΔPO2max: r = 0.718, p < 0.001; wash-in: r = -0.576, p = 0.003; wash-out skewness: r = -0.552, p = 0.004). Functional lung imaging using OE-MRI has the capability to assess the severity of CF lung disease and shows a significant correlation with LFT and CF-CT. • Oxygen-enhanced MRI might play a future role in evaluation and follow-up of cystic fibrosis. • Heterogeneity of parameter maps reflects localised functional impairment in cystic fibrosis. • Avoidance of cumulative radiation burden in CF is feasible using OE-MRI.
Databáze: OpenAIRE
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