Clearance of Sclerostin, Osteocalcin, Fibroblast Growth Factor 23, and Osteoprotegerin by Dialysis

Autor:	Ole Hartvig Mortensen, Nicholas Carlson, Robert Smith Pedersen, James G. Heaf, Mette Bjørndal Axelsen
Rok vydání:	2017
Předmět:	Male CHRONIC KIDNEY-DISEASE 0301 basic medicine Fibroblast growth factor 23 medicine.medical_treatment 030232 urology & nephrology HEMODIALYSIS-PATIENTS CHILDREN Fibroblast growth factor Bone remodeling chemistry.chemical_compound 0302 clinical medicine MAINTENANCE HEMODIALYSIS BONE-DISEASE VITAMIN-D PERITONEAL-DIALYSIS biology Chemistry Hematology General Medicine Middle Aged Nephrology Bone Morphogenetic Proteins Osteocalcin Clearance Female Genetic Markers musculoskeletal diseases medicine.medical_specialty Sclerostin PARATHYROID-HORMONE METABOLISM 03 medical and health sciences Osteoprotegerin Renal Dialysis Internal medicine medicine Humans HYPERPARATHYROIDISM Dialysis Adaptor Proteins Signal Transducing Aged Fibroblast Growth Factors Fibroblast Growth Factor-23 030104 developmental biology Endocrinology biology.protein Kidney Failure Chronic
Zdroj:	Carlson, N, Mortensen, O H, Axelsen, M, Pedersen, R S & Heaf, J G 2017, ' Clearance of Sclerostin, Osteocalcin, Fibroblast Growth Factor 23, and Osteoprotegerin by Dialysis ', Blood Purification, vol. 44, no. 2, pp. 122-128 . https://doi.org/10.1159/000465513
ISSN:	1421-9735 0253-5068
DOI:	10.1159/000465513
Popis:	Introduction: Fibroblast growth factor (FGF23), sclerostin, osteocalcin, and osteoprotegerin are important factors that control mineral bone metabolism. End-stage renal disease is associated with the pronounced dysregulation of mineral bone metabolism; however, the impact and clearance of mineral bone metabolism factors during dialysis remain largely undescribed. Methods: In a cross-sectional study, 10 chronic hemodialysis patients were treated with hemodialysis for 8 h using a high-flux filter and a dialysate bath of 50% calculated total body water continuously recycled at a rate of 500 mL/min. Plasma and dialysate concentrations of FGF23, sclerostin, osteoprotegerin, and osteocalcin were measured at 1, 2, 4, 6, and 8 h permitting the estimation of dialysis clearance. Results: Clearance of FGF23 was 7.7 mL/min, of sclerostin was 7.6 mL/min, of osteoprotegerin was 1.2 mL/min, and of osteocalcin was 19.7 mL/min. Clearance of FGF23 was correlated to sclerostin and osteoprotegerin clearance and also to the ultrafiltration rate. Although, osteocalcin blood concentrations decreased during dialysis, they rebounded within 6 h. Overall, no significant changes in blood concentrations of the measure mineral bone metabolism factors were observed. Conclusions: The intradialytic clearance of osteocalcin, FGF23, sclerostin, and osteoprotegerin occurs; however, only clearance of FGF23 is directly correlated with the ultrafiltration rate. The effects of dialytic clearance on mineral bone metabolism are, however, uncertain and intradialytic plasma concentrations of the studied substrates remained largely unchanged.
Databáze:	OpenAIRE
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