Experimental Studies on the Elimination of Radioiodine from the Body
| Autor: | G. Frerichs, W.E. Stumpf, E.H. Graul |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
medicine.medical_specialty
Dose Epidemiology Health Toxicology and Mutagenesis medicine.medical_treatment Guinea Pigs Thyroid Gland Thyrotropin chemistry.chemical_element Iodine Iodine Radioisotopes Hydrochlorothiazide Iodine Isotopes Internal medicine Abdomen medicine Ingestion Radiology Nuclear Medicine and imaging Radiation Injuries Radiometry Pharmacology Perchlorates Chemistry Research Stomach Thyroid Gastric lavage Radiation Injuries Experimental Metabolism medicine.anatomical_structure Endocrinology Potassium Diuretic medicine.drug |
| Zdroj: | Health Physics. 9:1411-1418 |
| ISSN: | 0017-9078 |
| DOI: | 10.1097/00004032-196312000-00051 |
| Popis: | An experimental study involving more than 250 guinea pigs was conducted in order to develop a therapeutic schedule for emergency treatment of acute radioiodine exposure. The effects of KClO/sub 4/, Iodine, TSH, and the diuretic hydrochlorthiazid, administered to animals in varying dosages at several tinre intervals following I/sup 131/ uptake, were examined on thyroid and whole-body levels of I/sup 131/. KClO/sub 4/ proved more effective than iodine in blocking the uptake of I/sup 131/ by thyroid. TSH treatment is contraindicated 24 hr after I/sup 131/ administration. A combined treatment with TSH and KClO/sub 4/ gives optimal results at time intervals exceeding 24 hr after administration of I/ sup 131/. It is proposed that gastric lavage (with injection of KCIO/sub 4/) be used within the first few hours following I/sup 131/ exposure. Ingestion of salivary secretions must also be avoided. (auth) |
| Databáze: | OpenAIRE |
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