Pulmonary tuberculosis in children with Hodgkin's lymphoma
| Autor: | Nermin Güler, Leyla Agaoglu, Sema Anak, Zeynep Karakas, Omer Devecioglu, Baki Taravari, Ayper Somer, Işık Yalçın, Ayşegül Ünüvar, Ebru Saribeyoglu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Pathology Tuberculosis Adolescent Antitubercular Agents Diagnosis Differential Pharmacotherapy Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Tuberculosis Pulmonary Retrospective Studies Lung business.industry Medical record Candidiasis Mediastinum Sputum Retrospective cohort study Hematology medicine.disease Hodgkin's lymphoma Hodgkin Disease Anti-Bacterial Agents Lymphoma medicine.anatomical_structure Child Preschool Drug Therapy Combination Female Lymph Nodes Neoplasm Recurrence Local Differential diagnosis Tomography X-Ray Computed business Bronchoalveolar Lavage Fluid |
| Zdroj: | The Hematology Journal. 4:78-81 |
| ISSN: | 1476-5632 1466-4860 |
| DOI: | 10.1038/sj.thj.6200219 |
| Popis: | The clinical presentation of tuberculosis (TB) and Hodgkin's lymphoma (HL) with pulmonary involvement is similar and raises problems of differential diagnosis. It may also be difficult to distinguish TB from relapsed lymphoma. The purpose of this study was to evaluate the association of HL and pulmonary TB and to discuss differential diagnosis. Medical records of 70 children were reviewed retrospectively. A total of 27 patients (38%) had mediastinal-pulmonary involvement initially. Systemic symptoms were present in 37 (52%) patients. In all, 14 patients (20%) had pulmonary TB; three of them were diagnosed as having TB before HL, two of them had TB and HL concomittantly at initial diagnosis, seven of them during lymphoma therapy and two of them after the cessation of lymphoma treatment. PPD was positive (>10 mm) only in seven patients. In all, 11 patients with pulmonary TB had diffuse pulmonary infiltrations and mediastinal enlargement at lung contrast-enhanced computed tomography and X-ray, which was difficult to differentiate from HL. Biopsies were performed in five patients. No mortality because of the infection was seen. Only one patient had been lost as relapsed-resistant HL. To evaluate mediastinal lymphadenopathies is very crucial and the differential diagnosis is difficult; hence the association between HL and the TB must be considered especially in countries where TB is highly endemic. |
| Databáze: | OpenAIRE |
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