Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component
| Autor: | Amir Bieber, Irina Novofastovski, Muhammad Asim Khan, Fabiola Atzeni, Pasquale Ambrosino, Jácome Bruges Armas, N. Pappone, Piercarlo Sarzi-Puttini, D. Kiefer, Reuven Mader, Xenofon Baraliakos, Iris Eshed, Jorrit-Jan Verlaan, Dan Buskila |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Diagnostic Imaging Pathology medicine.medical_specialty Axial skeleton Inflammation Enthesopathy 03 medical and health sciences 0302 clinical medicine Rheumatology Ankylosing hyperostosis Spondylarthritis medicine Humans Diffuse Idiopathic Skeletal Hyperostosis 030203 arthritis & rheumatology Ankylosing spondylitis Hyperostosis Diffuse Idiopathic Skeletal business.industry Ligamentous ossification Enthesitis medicine.disease 030104 developmental biology medicine.anatomical_structure Diffuse idiopathic skeletal hyperostosis (DISH) medicine.symptom business |
| Zdroj: | Current rheumatology reportsPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance. 23(1) |
| ISSN: | 1534-6307 |
| Popis: | Diffuse Idiopathic Skeletal Hyperostosis (DISH) is considered a metabolic condition, characterized by new bone formation affecting mainly at entheseal sites. Enthesitis and enthesopathies occur not only in the axial skeleton but also at some peripheral sites, and they resemble to some extent the enthesitis that is a cardinal feature in spondyloarthritis (SpA), which is an inflammatory disease. We review the possible non-metabolic mechanism such as inflammation that may also be involved at some stage and help promote new bone formation in DISH. We discuss supporting pathogenic mechanisms for a local inflammation at sites typically affected by this disease, and that is also supported by imaging studies that report some similarities between DISH and SpA. Local inflammation, either primary or secondary to metabolic derangements, may contribute to new bone formation in DISH. This new hypothesis is expected to stimulate further research in both the metabolic and inflammatory pathways in order to better understand the mechanisms that lead to new bone formation. This may lead to development of measures that will help in earlier detection and effective management before damage occurs. |
| Databáze: | OpenAIRE |
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