Cytotoxic stilbenes from the roots of Paphiopedilum godefroyae

Autor:	Chutichot Pattamadilok, Rutt Suttisri, Ladapa Khankhampoch, Nonthalert Lertnitikul, Punyada Jittham, Suchada Sukrong
Rok vydání:	2016
Předmět:	Stereochemistry Pharmaceutical Science Plant Roots 01 natural sciences Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Paphiopedilum godefroyae Stilbenes Drug Discovery Humans Cytotoxic T cell Benzofuran Orchidaceae Cytotoxicity IC50 Benzofurans Pharmacology Molecular Structure biology 010405 organic chemistry Organic Chemistry General Medicine Thailand biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Cell culture Flavanones Molecular Medicine Drug Screening Assays Antitumor Flavanone Derivative (chemistry)
Zdroj:	Journal of Asian Natural Products Research. 18:1143-1150
ISSN:	1477-2213 1028-6020
DOI:	10.1080/10286020.2016.1183651
Popis:	Two new stilbenes, 2-(3',5'-dimethoxyphenyl)-6-hydroxy-5-methoxybenzofuran (1) and 3'-hydroxy-2,5'-dimethoxystilbene (2), together with seven known stilbenes (3, 5-10) and one flavanone (4), were isolated from the roots of Paphiopedilum godefroyae. Their chemical structures were determined on the basis of their spectroscopic data. These isolated compounds were evaluated for their cytotoxicity against human small cell lung cancer (NCI-H187) cell lines and an arylbenzofuran derivative, 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (6), was shown to be strongly cytotoxic with an IC50 value of 5.10 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68144122a1c34566d1205a1e286360ea https://doi.org/10.1080/10286020.2016.1183651 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.