Supplementary Figure 2 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma
| Autor: | Amy B. Heimberger, George A. Calin, Gregory N. Fuller, Ganesh Rao, Frederick F. Lang, Nicholas B. Levine, Wei Qiao, Olsi Gjyshi, Krishan Jethwa, Kayla McEnery, Yuhui Yang, Sherise D. Ferguson, Tiffany Doucette, Shuo Xu, Ling-Yuan Kong, Fei Wang, Jun Wei |
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| Rok vydání: | 2023 |
| Popis: | Supplementary Figure 2 - PDF file 25K, Schema demonstrating how miR-124 exerts target effects on the STAT3 pathway in gCSC cells. STAT3 can be activated by a variety of ligands such as IL-6 or EGFR. miR-124 can not only down-modulate SHC1, STAT3, P-STAT3 in all tested gCSC cell lines but also, occasionally, pMAPK1/3, probably in a contextual fashion when the IL-6R ligand is not present and the gCSC is dependent on EGFR signaling |
| Databáze: | OpenAIRE |
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