The Comparative Effects of Risperidone Long-Acting Injection and Paliperidone Palmitate on Social Functioning in Schizophrenia: A 6-Month, Open-Label, Randomized Controlled Pilot Trial
| Autor: | Keiichiro Nishida, Masaki Kato, Yosuke Koshikawa, Chiara Fabbri, Naotaka Sunada, Yoshiteru Takekita, Toshihiko Kinoshita, Alessandro Serretti, Masafumi Yoshimura, Ai Onohara, Shiho Sakai |
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| Přispěvatelé: | Koshikawa, Yosuke, Takekita, Yoshiteru, Kato, Masaki, Sakai, Shiho, Onohara, Ai, Sunada, Naotaka, Nishida, Keiichiro, Yoshimura, Masafumi, Fabbri, Chiara, Serretti, Alessandro, Kinoshita, Toshihiko |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Efficacy Pilot Projects Neuropsychological Tests Risperidone long-acting injection law.invention 03 medical and health sciences 0302 clinical medicine Japan Extrapyramidal symptoms Randomized controlled trial law Social functioning Paliperidone Palmitate medicine Humans Pilot Project Social Behavior Psychiatry Biological Psychiatry Risperidone Positive and Negative Syndrome Scale business.industry Cognition Middle Aged 030227 psychiatry Psychiatry and Mental health Antipsychotic Agent Treatment Outcome Neuropsychology and Physiological Psychology Long acting Schizophrenia Physical therapy Neuropsychological Test Female medicine.symptom business 030217 neurology & neurosurgery Human Antipsychotic Agents medicine.drug |
| Zdroj: | Neuropsychobiology. 73:35-42 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000442209 |
| Popis: | Purpose: The aim of this study was to compare the effects of risperidone long-acting injection (RLAI) and paliperidone palmitate (PP) on non-acute-phase social functioning in patients with schizophrenia. Patients and Methods: In this 6-month pilot, open-label, randomized controlled study, 30 patients with schizophrenia who had been treated with RLAI were randomly allocated to the RLAI continuation group or switched to the PP group. Patients were evaluated at baseline and 6 months with the Social Functioning Scale (SFS) as the primary outcome variable and University of California San Diego Performance-Based Skills Assessment Brief (UPSA-B), Social Emotional Cognition Task (SECT), Positive and Negative Syndrome Scale (PANSS), and Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) scores as secondary outcomes. Results: At baseline, the two groups did not significantly differ in demographic or clinical features. The two groups did not differ in total score changes for the UPSA-B, the SECT, the PANSS, and the DIEPSS. However, the total scores and the two subscales of the SFS, i.e. independence-competence and independence-performance, were more improved in the PP group compared to the RLAI group (total scores, p = 0.038; competence, p = 0.001, and performance, p = 0.007, respectively). Conclusion: These results suggest that PP may improve the total social functioning, independent life competence, and performance as compared to the RLAI group. However, these results are preliminary and need independent replication in larger samples before any definitive statement can be made. |
| Databáze: | OpenAIRE |
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