The avidity of PR3-ANCA in patients with granulomatosis with polyangiitis during follow-up

Autor: Jan Damoiseaux, Wolfgang Schlumberger, Cornelia Dähnrich, J. W. Cohen Tervaert, Michael J. Kemna, P. Van Paassen
Přispěvatelé: Promovendi CD, MUMC+: MA Nefrologie (9), MUMC+: MA Klinische Immunologie (9), MUMC+: DA CDL Algemeen (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Medische Microbiologie, RS: NUTRIM - R4 - Gene-environment interaction
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Myeloblastin
Immunology
Antibody Affinity
ANCA-Associated Vasculitis
urologic and male genital diseases
Gastroenterology
Antibodies
Antineutrophil Cytoplasmic
03 medical and health sciences
0302 clinical medicine
Proteinase 3
Recurrence
avidity
Internal medicine
follow-up
Immunology and Allergy
Medicine
Humans
In patient
Avidity
cardiovascular diseases
skin and connective tissue diseases
PR3-ANCA
Aged
030203 arthritis & rheumatology
relapse
relative avidity index
granulomatosis with polyangiitis
business.industry
Antibody affinity
Original Articles
Cytoplasmic antibody
Middle Aged
medicine.disease
proteinase 3
030104 developmental biology
Female
Kidney Diseases
business
Granulomatosis with polyangiitis
ANCA-associated vasculitis
Follow-Up Studies
Zdroj: Clinical and Experimental Immunology, 185(2), 141-147. Wiley
ISSN: 0009-9104
Popis: Summary The objective of this study is to investigate whether the avidity of proteinase-3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) changes during follow-up in different subgroups of patients with granulomatosis with polyangiitis (GPA). We selected 10 patients with renal relapsing GPA, 10 patients with renal non-relapsing GPA and 10 patients with non-renal relapsing GPA. In all patients, an ANCA rise occurred during remission. The avidity was measured using a chaotropic approach at the time of an ANCA rise and at the time of a relapse in relapsing patients or time-matched during remission in non-relapsing patients. No difference was observed in the avidity at the ANCA rise between renal relapsing patients [26·2% (15·5–47·5)], renal patients without a relapse [39·6% (21·2–63·4)] and non-renal relapsing patients [34·2% (21·6–59·5)]. In renal relapsing patients, the avidity increased significantly from the moment of the ANCA rise to the relapse [difference 6·4% (0·0–17·1), P = 0·0273]. The avidity did not increase after an ANCA rise in renal non-relapsing patients [difference 3·5 (−6·0 to 10·1), P = 0·6250] or in non-renal relapsing patients [difference −3·1% (−8·0 to 5·0), P = 0·5703]. The avidity of PR3-ANCA increases after an ANCA rise during follow-up in renal relapsing patients, but not after an ANCA rise in renal patients who remain in remission or in non-renal relapsing patients.
Databáze: OpenAIRE
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