Involvement of chronic epipharyngitis in autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)
| Autor: | Osamu Hotta, Kazuaki Imai, Norio Ieiri, Ayaki Tanaka, Akira Torigoe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Allergy Adolescent medicine.medical_treatment Immunology Autoimmune Diseases Immunologic activation Pathogenesis 03 medical and health sciences Young Adult 0302 clinical medicine Immune system Adjuvants Immunologic medicine Humans Papillomavirus Vaccines Adjuvants Pharmaceutic 030203 arthritis & rheumatology Autoimmune disease business.industry Vaccination Respiratory infection Pharyngeal Diseases Syndrome medicine.disease 030104 developmental biology Pharynx Female business Adjuvant |
| Zdroj: | Immunologic research. 65(1) |
| ISSN: | 1559-0755 |
| Popis: | The epipharynx is an immunologically active site even under normal conditions, and enhanced immunologic activation is prone to occur in response to an upper respiratory infection, air pollution, and possibly to vaccine adjuvants. Due to the potential link between the central nervous system and immune function, a relationship between epipharyngitis and autonomic nervous disturbance as well as autoimmune disease has been suggested. Various functional somatic symptoms have been described after human papillomavirus (HPV) vaccination, although a causal relationship has not been established. We examined the epipharynx in young women showing functional somatic symptoms following HPV vaccination. Surprisingly, despite having minimal symptoms involving the pharynx, all patients were found to have severe epipharyngitis. In addition, significant improvement in symptoms was seen in most patients who underwent epipharyngeal treatment. Thus, we speculate that the chronic epipharyngitis potentially caused by the vaccine adjuvant may be involved in the pathogenesis of functional somatic syndrome (FSS) post-HPV vaccination. Further, we suggest that epipharyngeal treatment may be effective for various types of FSS regardless of the initial cause, as well as for some autoimmune diseases, and that this may be an important direction in future research. |
| Databáze: | OpenAIRE |
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